Efficacy of Preventive Chemotherapy of Tuberculosis in HIV Infected Patients in Novosibirsk Oblast

The objective : to study the efficacy of tuberculosis preventive chemotherapy in HIV infected patients based on data AIDS Prevention and Control Center, which is a part City Infectious Clinical Hospital no. 1, Novosibirsk. Subjects Methods . 236 aged 33-48 years old were enrolled study, they all registered All at stage secondary diseases (4A, 4B, 4C), had pronounced degree immunodeficiency (CD4+ from 200 349 cells/µl), ongoing ART was virologically successful. (CTX) analyzed 147 versus 89 who received no CTX due various reasons. For chemotherapy, combination drug used, contained isoniazid pyrazinamide, for 3 months with daily intake. groups those receiving not comparable terms gender, age immunodeficiency. Results In group within year after completion CTX, diagnosed 7/147 (4.8%) including: focal pulmonary - 71.4% (5/7), infiltrative 28.6% (2/7 patients). during year, 17/89 (19.1%) cases detected: – 29.4% (5/17), 47.1% (8/17), disseminated 23.5% (4/17). Disseminated only CTX. relative risk (RR = 0.442 (<1)) when comparing number indicates lower likelihood develop taking odds ratio (OR 0.212; CI 0.084-0.534) that chances developing are higher Conclusion use pyrazinamide significantly reduces tuberculosis. Patients severe have contraindications should be followed up jointly phthisiologist, follow-up include computed tomography early detection signs lungs.